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After seventeen years in prison, the former respected Parisian banker Paul Lavond flees with his friend, the lunatic scientist Marcel that is researching with his wife Malita the miniaturization of animals and human beings to improve the resources of mankind. Paul Lavond was framed for robbery by his scoundrel associates Emil Coulvet, Charles Matin and Victor Radin that had sto...。某天，心理学学生艾比·琼斯（Christine Evangelista 饰）随同学还有教授一同前往帕克精神病院观摩。早在3年前，艾比罹患精神病的父亲便在这所医院自杀。可是为了帮更多患者走出阴影，这个勤奋勇敢的女孩还是踏入了这幢充满恐慌的建筑。在此期间，艾比意外遭到橙色高危精神病患者哈蒙（Dominic Purcell 饰）的袭击，备受惊吓。观摩结束之后，艾比返回寓所，与莱妮（Melissa Ordway 饰）和琳（Carly Chaikin 饰）两名好友进行考前复习。与此同时，哈蒙袭击看守人员后逃跑。警方在调查过程中发现，艾比与哈蒙被捕前杀害的女友十分相像。恶魔出笼，新的杀戮似乎即将展开…… 本片根据制作人位于路易斯安那州的家乡发生的真实事件改编。。